| Bioactivity | NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. |
| Invitro | NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3].NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3]. Cell Viability Assay Cell Line: |
| Name | NSC-87877 |
| CAS | 56990-57-9 |
| Formula | C19H13N3O7S2 |
| Molar Mass | 459.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
NSC-87877
CAS: 56990-57-9 F: C19H13N3O7S2 W: 459.45
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values o
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