| Bioactivity | BAI1 is a selective and allosteric inhibitor of BAX, an apoptosis regulator. BAI1 directly binds to BAX and allosterically inhibits BAX activation. BAI1 has the potential for the research of diseases mediated by BAX-dependent cell death[1]. | ||||||||||||
| Invitro | BAI1 selectively inhibits BAX-mediated apoptotic cell death[1].BAI1 shows inhibition of tBID (HY-100464)-induced BAX-mediated membrane permeabilization in a dose dependent manner with an IC50 of 3.3 μΜ[1]. Apoptosis Analysis[1] Cell Line: | ||||||||||||
| Name | BAI1 | ||||||||||||
| CAS | 335165-68-9 | ||||||||||||
| Formula | C19H21Br2N3O | ||||||||||||
| Molar Mass | 467.20 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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