| Bioactivity | NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate[1]. |
| Target | IC50: 6.0 nM (NS2B/NS3) |
| Invitro | NS2B/NS3-IN-2 (compound 23) (150 nM) shows 100% inhibition rate against Dengue virus (DENV)[1].NS2B/NS3-IN-2 (5 µM) shows no cytotoxicity and markedly increases the cell survival rate[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| Name | NS2B/NS3-IN-2 |
| Formula | C24H21N3O5S |
| Molar Mass | 463.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lin X,et al. Identification and In Silico Binding Study of a Highly Potent DENV NS2B-NS3 Covalent Inhibitor. ACS Med Chem Lett. 2022; 13(4):599-607. |