| Bioactivity | Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1]. |
| Target | IC50: 0.10 μM (Trypanosoma cruzi) |
| Invitro | Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.10 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. Animal Model: |
| Name | Anti-infective agent 5 |
| CAS | 2738381-47-8 |
| Formula | C18H13N5O3 |
| Molar Mass | 347.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ang CW, et al. Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection. J Med Chem. 2022 Sep 16. |
Anti-infective agent 5
CAS: 2738381-47-8 F: C18H13N5O3 W: 347.33
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM.
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