| Bioactivity | NPC26 is a small molecule mitochondrial disruptor with anti-tumor activity. NPC-26 shows significant anti-proliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 can damage mitochondrial function, leading to the opening of the mitochondrial permeability transition pore (mPTP) and the production of reactive oxygen species, ultimately inducing cell death. NPC-26 can kill CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway[1]. |
| CAS | 864860-32-2 |
| Formula | C19H23N3O5S2 |
| Molar Mass | 437.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhen Zhao, et al. NPC-26 kills human colorectal cancer cells via activating AMPK signaling. Oncotarget. 2017 Feb 17;8(11):18312–18321. |