| Bioactivity | NA-17 is a naphthalimide compound with anti-tumor activity and lower toxicity to normal cells like HL-7702 and WI-38. NA-17 exhibits a p53-dependent selective inhibition in various NSCLC cells, inducing the accumulation of active p53 in the mitochondria and nuclei of NSCLC cells. NA-17 can cause cell cycle arrest in the G1 phase, leading to apoptosis and cell death[1]. |
| CAS | 1708948-28-0 |
| Formula | C26H27N3O4 |
| Molar Mass | 445.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guohai Zhang, et al. A Novel Naphthalimide Compound restores p53 function in Non–Small–Cell by Reorganizing the Bak–Bcl-xl Complex and Triggering Transcriptiona regulation. JBC. December 14, 2015. |