| Bioactivity | NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM[1]. |
| Invitro | NP-BTA (300 μM) 通过与 His6-Gln4 结合 (KD 为 180 nM)，抑制 GlnRS，抑制 tRNAGln 的氨酰化，IC50 为 106 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NP-BTA 相关抗体: |
| In Vivo | NP-BTA (0.096–0.27 g 2% NP-BTA cream，每天涂抹两次，共 7 天) 可保护免疫抑制的 CD-1 小鼠免受 T. mentagrophytes 分生孢子的感染[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 544420-99-7 |
| Formula | C11H9N3OS |
| Molar Mass | 231.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Puumala E, et al., Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity. Cell Chem Biol. 2024 Apr 18;31(4):760-775.e17. |
NP-BTA
CAS: 544420-99-7 F: C11H9N3OS W: 231.27
NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Ca
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