| Bioactivity | NOS-IN-2 (Compound 4i) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 20 µM, without inhibiting eNOS. NOS-IN-2 has little toxicity and can be used for studying inflammatory disorders[1]. |
| Target | IC50: 20 µM (iNOS), > 1000 µM (nNOS) |
| Invitro | NOS-IN-2 (Compound 4i) shows high iNOS selectivity without eNOS inhibition activity [1].NOS-IN-2 (0-100 µM, 30 min) has little toxicity[1]. Cell Viability Assay[1] Cell Line: |
| In Vivo | NOS-IN-2 (Compound 4i) is predicted to show oral bioavailability[1]. |
| Name | NOS-IN-2 |
| Formula | C18H20F3N3O2 |
| Molar Mass | 367.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fabio Arias, et al. Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors. Bioorg Med Chem. 2021 Aug 15;44:116294. |