Epobis_product_DataBase

Bioactivity	Epobis, a dendrimeric peptide, is a recombinant form of erythropoietin. Epobis is a potent erythropoietin receptor agonist. Epobis promotes neuritogenesis in primary motoneurons. Epobis decrease TNF release and crosses the blood-brain barrier. Epobis has anti-inflammatory and memory enhancing properties[1].
Invitro	Epobis (0-8.82 μM) stimulates neurite outgrowth from motor neurons in a dose-dependent manner with maximal stimulation at 0.33 μM[1].Epobis (0-8.82 μM; 24 h) reduces release of TNF and improves the survival of the L929 cells[1]. Cell Viability Assay[1] Cell Line:
In Vivo	Epobis (10 mg/kg; i.h.; Wistar rats) can cross the blood-brain barrier (BBB)[1].Epobis (10 mg/kg; i.h.) has an anti-inflammatory effect in mice of multiple sclerosis model[1].Epobis (10 mg/kg; i.h.; old (>18 month) rats and in rats experiencing early stage AD) improves social memory[1]. Animal Model:
Name	Epobis
CAS	915091-83-7
Shortening	NENITVPDTKVNFYAWKR
Formula	C100H151N27O29
Molar Mass	2195.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Dmytriyeva O, et, al. Epobis is a Nonerythropoietic and Neuroprotective Agonist of the Erythropoietin Receptor with Anti-Inflammatory and Memory Enhancing Effects. Mediators Inflamm. 2016;2016:1346390.

PeptideDB