| Bioactivity | NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs[1]. |
| Name | NOD2 antagonist 1 |
| CAS | 2411441-54-6 |
| Formula | C26H26N4O3S |
| Molar Mass | 474.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guzelj S, et al. Structural features and functional activities of benzimidazoles as NOD2 antagonists. Eur J Med Chem. 2020;190:112089. |
NOD2 antagonist 1
CAS: 2411441-54-6 F: C26H26N4O3S W: 474.57
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 in
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