| Bioactivity | NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain[1][2]. |
| Name | NMB-1 |
| CAS | 2843557-76-4 |
| Sequence | Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Phe-Cys-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys10) |
| Shortening | FNWRCCLIPCRRNHKKFFC-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys10) |
| Formula | C111H164N36O21S4 |
| Molar Mass | 2466.98 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Drew LJ, et al. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One. 2007 Jun 13;2(6):e515. [2]. Raouf R, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Sci Signal. 2018 Jun 19;11(535):eaao2060. |
NMB-1
CAS: 2843557-76-4 F: C111H164N36O21S4 W: 2466.98
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons
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