NLRP3-IN-9_product_DataBase

Bioactivity	NLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout[1].
Invitro	NLRP3-IN-9 (compound 4b) (0.01-3 µM) 在 ATP (5 mM) 和 LPS (1 µg/mL) 诱导的巨噬细胞中以剂量依赖性方式抑制 IL-1β 释放[1].NLRP3-IN-9 (1 µM; 15 min) 抑制 NLRP3 炎性体寡聚化[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	NLRP3-IN-9 (3, 10 mg/kg; i.p.) 减少急性痛风小鼠模型中的炎症和机械痛觉[1]。 Animal Model:
Name	NLRP3-IN-9
CAS	2768759-64-2
Formula	C16H19N2NaO5S
Molar Mass	374.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Narros-Fernández P, et al. Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout. J Med Chem. 2022 Apr 28;65(8):6250-6260.

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