| Bioactivity | NLRP3-IN-60 (Compound 39) is the orally active inhibitor for NLRP3. NLRP3-IN-60 inhibits pyroptosis with an IC50 of 13 nM in THP-1 cell. NLRP3-IN-60 inhibits IL-1β release with an IC50 of 225 nM in human whole blood[1]. |
| Formula | C23H24F2N4O4S |
| Molar Mass | 490.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mesch S, et al., Novel Macrocyclic NLRP3 Inhibitors. J Med Chem. 2024 Dec 12;67(23):20911-20932. |