| Bioactivity | Lu AF90103 (Compound 42e) is a methyl ester prodrug of compound 42d capable of penetrating the blood–brain barrier. Compound 42d acts as a partial agonist of the GluN1/GluN2B complex, exhibiting 24% efficacy, and has an EC50 value of 78 nM. Lu AF90103 plays an important role in neuropsychiatric diseases research[1]. |
| CAS | 2577196-14-4 |
| Formula | C13H15N3O3S |
| Molar Mass | 293.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Erhad Ascic, et al. Advancements in NMDA Receptor-Targeted Antidepressants: From d-Cycloserine Discovery to Preclinical Efficacy of Lu AF90103. J Med Chem. 2024 Nov 28;67(22):20135-20155. |
Lu AF90103
CAS: 2577196-14-4 F: C13H15N3O3S W: 293.34
Lu AF90103 (Compound 42e) is a methyl ester prodrug of compound 42d capable of penetrating the blood–brain barrier. Com
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