| Bioactivity | NLRP3-IN-43 (compound II-8) is a poteny inhibitor of NLRP3 inflammasome activation that binds to the LRR domain, and disrupts NLRP3-NEK7 interaction[1]. |
| CAS | 2769903-01-5 |
| Formula | C25H31N5OS |
| Molar Mass | 449.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bing-Yan Li, et al. Discovery and Development of NLRP3 Inhibitors Targeting the LRR Domain to Disrupt NLRP3-NEK7 Interaction for the Treatment of Rheumatoid Arthritis. J Med Chem. 2024 Jun 27;67(12):9869-9895. |
NLRP3-IN-43
CAS: 2769903-01-5 F: C25H31N5OS W: 449.61
NLRP3-IN-43 (compound II-8) is a poteny inhibitor of NLRP3 inflammasome activation that binds to the LRR domain, and dis
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