NLRP3-IN-17_product_DataBase

Bioactivity	NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research[1].
In Vivo	NLRP3-IN-17 (3 mg/kg; po) 显示良好的PK 数据，AUC、t1/2 和 F% 值分别为 4.2 μg.h/mL、2.91 h 和 56%[1]。 NLRP3-IN-17 (10 mg/kg; P.O.; 单剂量) 显著抑制 NLRP3 依赖性 IL-1β 的分泌，使急性体内 LPS+ATP 刺激模型雌性 C57BL/6 小鼠 IL-1β 水平降低了44%[1]。
Name	NLRP3-IN-17
CAS	2254432-75-0
Formula	C21H22N4O2S
Molar Mass	394.49
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sameer Agarwal, et al. Discovery of N-Cyano-sulfoximineurea Derivatives as Potent and Orally Bioavailable NLRP3 Inflammasome Inhibitors. ACS Med Chem Lett. 2020 Feb 27;11(4):414-418.

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