Ac-VLPE-FMK_product_DataBase

Bioactivity	Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. Ac-VLPE-FMK can be used for the research of cancer aggressiveness[1][2].
Invitro	Ac-VLPE-FMK (2 μM) 显着影响人重组 CtsB 和 L 对探针 Ac-PLVQ-AMC 的裂解[1]。Ac-VLPE-FMK (30 min) 抑制 769-p 和 A498 细胞中底物 Ac-PLVQ-AMC 裂解产生的荧光[1]。Ac-VLPE-FMK (2.5-250 μM; 24-72 h) 不影响肾癌细胞活力，但影响肾癌细胞的细胞迁移率、细胞粘附、集落形成和标志物表达[1]。
Name	Ac-VLPE-FMK
CAS	2679825-27-3
Formula	C25H41FN4O7
Molar Mass	528.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rudzińska M, et, al. Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype. Cancers (Basel). 2020 May 21;12(5):1310. [2]. Citarella A, et, al. Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry. Molecules. 2020 Sep 3;25(17):4031.

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