| Bioactivity | NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages[1]. |
| CAS | 2409826-23-7 |
| Formula | C22H28ClN5O2S |
| Molar Mass | 462.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vande Walle L, et al. Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency. Life Sci Alliance. 2024 Mar 22;7(6):e202402644. |
NIC-12
CAS: 2409826-23-7 F: C22H28ClN5O2S W: 462.01
NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice mod
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