| Bioactivity | DNMT/HDAC-IN-1 (Compund 15a) is a dual DNMT and HDAC inhibitor with IC50 values for HDAC1 and HDAC6 are 56.84 nM and 17.39 nM respectively. DNMT/HDAC-IN-1 can induce apoptosis and be used in tumor research. |
| Invitro | DNMT/HDAC-IN-1 显著抑制 K562 和 U937 增殖，IC50 值分别为 2.85 和 1.06 mM。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> DNMT/HDAC-IN-1 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Animal Model: |
| CAS | 2095619-17-1 |
| Formula | C19H16ClF3N2O3 |
| Molar Mass | 412.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuan Z, et al. Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors. Eur J Med Chem. 2017 Jul 7;134:281-292. [2]. Huang W, et al. Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer. Cell Death Discov. 2024 Mar 15;10(1):143. |
DNMT/HDAC-IN-1
CAS: 2095619-17-1 F: C19H16ClF3N2O3 W: 412.79
DNMT/HDAC-IN-1 (Compund 15a) is a dual DNMT and HDAC inhibitor with IC50 values for HDAC1 and HDAC6 are 56.84 nM and 17.
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