| Bioactivity | NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels[1][2]. | ||||||||||||
| Invitro | NBD-556 (1-100 μM) inhibits HIV-1 envelope-mediated virus-cell and cell-cell fusion[1].NBD-556 inhibits the infection of MT-2 cells by laboratory-adapted HIV-1 IIIB, MN, and V32 strains, with IC50s of 6.5, 15.9, and 5.3 µM, respectively[1].NBD-556 (1-100 μM) inhibits the CD4-dependent virus in a dose-dependent manner with an IC50 of 22.6 μM[1]. | ||||||||||||
| Name | NBD-556 | ||||||||||||
| CAS | 333353-44-9 | ||||||||||||
| Formula | C17H24ClN3O2 | ||||||||||||
| Molar Mass | 337.84 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zhao Q, Ma L, Jiang S, Lu H, Liu S, He Y, Strick N, Neamati N, Debnath AK. Identification of N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4. Virology. 2005 Sep 1;339 [2]. Schon A, et al. Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. Biochemistry. 2006 Sep 12;45(36):10973-10980. |
NBD-556
CAS: 333353-44-9 F: C17H24ClN3O2 W: 337.84
NBD-556, a CD4 mimetic, is a potent HIV-1 entry inhibitor that blocks the gp120-CD4 interaction. NBD-556 shows potent ce
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