| Bioactivity | Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection[1][2][5]. | ||||||||||||
| Invitro | Bithionol sulfoxide (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water[1].Bithionol sulfoxide (1-1000 μg/plate) exhibits mutagenic activity, in the absence of metabolic activation, in strains TA98 and TA100 (in Salmonella/mammalian microsome test)[5]. | ||||||||||||
| In Vivo | Bithionol sulfoxide (oral administration) shows LD50 values of 1000-5000 mg/kg (mice) and about 5000 mg/kg (rats), and increased serum AST at high doses (5000-100 mg/kg)[3].Bithionol sulfoxide (80 and 90 mg/kg, oral administration) is effective against natural rumen fluke infections in dairy cattle[4]. Animal Model: | ||||||||||||
| Name | Bithionol (sulfoxide) | ||||||||||||
| CAS | 844-26-8 | ||||||||||||
| Formula | C12H6Cl4O3S | ||||||||||||
| Molar Mass | 372.05 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. [2]. S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. [3]. Lavrič A, et al. Oral toxicity of bithionol sulfoxide in mice and rats. Zbornik Veterinarske Fakultete Univerza Ljubljana 1990 Vol.27 No.1 pp.33-39 ref.22. [4]. Chompoochan T, et al. The anthelmintic effects of bithionol sulfoxide against sheep experimentally infected with Fasciola gigantica[C]//ACIAR PROCEEDINGS. 1996: 189-194. [5]. D.Mourot, et al. Mutagenicity of bithionol sulfoxide and its metabolites in the Salmonella/mammalian microsome test. Mutation Research/Genetic Toxicology, 1987, 188(1): 53-55. |
Bithionol (sulfoxide)
CAS: 844-26-8 F: C12H6Cl4O3S W: 372.05
Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulf
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