| Bioactivity | NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc[1]. |
| Sequence | Thr-Ala-Leu-Cys-Trp-Cys-Trp-Leu-Gln-Thr-Glu (Cyclo(Cys4-2(4F-Ph)-Cys6) |
| Shortening | TALCWCWLQTE (Cyclo(Cys4-2(4F-Ph)-Cys6) |
| Formula | C73H86F8N14O17S2 |
| Molar Mass | 1647.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li S, et al. Development of a Decafluorobiphenyl Cyclized Peptide Targeting the NEMO–IKKα/β Interaction that Enhances Cell Penetration and Attenuates Lipopolysaccharide-Induced Acute Lung Injury[J]. Bioconjugate Chemistry, 2024. |