| Bioactivity | N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 values of 55 µM and 37 µM for Cav1.2 and Cav1.3, respectively[1][2]. |
| Invitro | Flurazepam's long-acting metabolite, N-Desalkylflurazepam, reduces the amplitudes of all the evoked potentials (EPs) components[1]. |
| Name | N-Desalkylflurazepam |
| CAS | 2886-65-9 |
| Formula | C15H10ClFN2O |
| Molar Mass | 288.70 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. J J Kulikowski, et al. Are the amplitudes of visual evoked potentials sensitive indices of hangover effects after repeated doses of benzodiazepines? Psychopharmacology Suppl. 1984;1:154-64. [2]. Damien E Earl, et al. Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther. 2011 Apr;337(1):301-11. |
N-Desalkylflurazepam
CAS: 2886-65-9 F: C15H10ClFN2O W: 288.70
N-Desalkylflurazepam (Norfludiazepam) is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Des
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