N,N'-Dimethylhydrazine dihydrochloride_product_DataBase

Bioactivity	N,N'-Dimethylhydrazine (1,2-Dimethylhydrazine) dihydrochloride is a tumor inducer that induces colon tumors in rodents[1][2].
In Vivo	N,N'-Dimethylhydrazine (DMH) (20 mg/kg; sc; 每周一次, 24 wk) 可在 ICR 小鼠体内诱导结肠癌[1]。N,N'-Dimethylhydrazine (20 mg/kg; sc; 20 wk) 在大鼠腹腔内诱导肠癌肿瘤，这种作用会被嗜酸乳杆菌有效抑制。食用模拟“西方”饮食的牛肉饮食的老鼠比谷物喂养的老鼠患结肠癌的几率更高 (分别为 83% 和 31%)[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	306-37-6
Formula	C2H10Cl2N2
Molar Mass	133.02
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Nakamura S, et al. Morphogenesis of colonic adenomas in mice treated with N,N'-dimethylhydrazine dihydrochloride. Acta Pathol Jpn. 1982 May;32(3):473-81. [2]. Goldin BR, et al. Effect of Lactobacillus acidophilus dietary supplements on 1,2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats. J Natl Cancer Inst. 1980 Feb;64(2):263-5.

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