Adamantanine_product_DataBase

Bioactivity	Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5[1].
In Vivo	Adamantanine (500 mg/kg，腹腔注射，单剂量；1000 mg/kg，口服，单剂量) 作为精细粉碎的悬浮液在 Sprague Dawley 大鼠模型中不具备毒性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	42381-05-5
Formula	C11H17NO2
Molar Mass	195.26
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Nagasawa HT, et al., Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem. 1975 Aug;18(8):826-30. [2]. Nagaswa HT, et al., 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16(7):823-6.

PeptideDB