| Bioactivity | M-89 is a highly potent and specific menin inhibitor, with a Kd of 1.4 nM for binding to menin. M-89 inhibits the menin-mixed lineage leukemia (Menin-MLL) protein-protein interaction and has potential to treat MLL leukemia[1]. | ||||||||||||
| Target | Kd: 1.4 nM (menin). | ||||||||||||
| Name | M‑89 | ||||||||||||
| CAS | 2363165-42-6 | ||||||||||||
| Formula | C37H47N5O4S | ||||||||||||
| Molar Mass | 657.87 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Aguilar A, et al. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction. J Med Chem. 2019 Jul 11;62(13):6015-6034. |