| Bioactivity | Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 µg/mL for inhibiting HCV infection[1][2][3]. | |||||||||
| Invitro | Myriocin (Thermozymocidin; 0-10000 nM; 96 h; Huh7/Rep-Feo cells) inhibits the replication of a subgenomic hepatitis C virus (HCV) genotype 1b replicon[2].Myriocin (100 nM; 72 h) decreases in the sphingomyelin content of Huh7 cells[2]. Western Blot Analysis[2] Cell Line: | |||||||||
| Name | Myriocin | |||||||||
| CAS | 35891-70-4 | |||||||||
| Formula | C21H39NO6 | |||||||||
| Molar Mass | 401.54 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
|