| Bioactivity | Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy[1][2]. | ||||||||||||
| Invitro | Isoginkgetin (0-20 μM, 24 h) inhibits cell invasion in a dose-dependent manner[1].Isoginkgetin (10 μM, 0-24 h) induces the accumulation of ubiquitinated protein cargo into perinuclear aggregates, activates autophagy and induces lysosomal swelling, repositioning, and acidification[2].Isoginkgetin (10 μM, 0-6 h) induces ER stress, impairs the unfolded protein response, and results in accumulation of ERAD substrates[2].Isoginkgetin directly inhibits the chymotrypsin-, trypsin-, and caspase-like activities of the 20S proteasome and impairs NF-κB signaling[2].Isoginkgetin (30 μM, 0-24 h) induces apoptosis in MM cell lines[2]. Cell Invasion Assay[1] Cell Line: | ||||||||||||
| Name | Isoginkgetin | ||||||||||||
| CAS | 548-19-6 | ||||||||||||
| Formula | C32H22O10 | ||||||||||||
| Molar Mass | 566.51 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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