| Bioactivity | MurA-IN-3 is a reversible pyrrolidinedione-based MurA inhibitor. MurA-IN-3 has inhibitory activity for MurA with an IC50 value of 4.5 μM. MurA-IN-3 also has antibacterial activity[1]. |
| Target | IC50: 4.5 μM (MurA); 4.9 μM (C115D MurA mutant). |
| Invitro | MurA-IN-3 has inhibitory activity for MurA and C115D MurA mutant with IC50 values of 4.5 μM and 4.9 μM, respectively[1].MurA-IN-3 (0-100 μM; 24 h) has no cytotoxicity on both MRC-5 and HepG2 cell lines[1].MurA-IN-3 has antibacterial activity and pronounced stability[1]. |
| Name | MurA-IN-3 |
| Formula | C27H23ClN2O5S |
| Molar Mass | 523.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Reem K Fathalla, et al. Identification and Biochemical Characterization of Pyrrolidinediones as Novel Inhibitors of the Bacterial Enzyme MurA. J Med Chem. 2022 Nov 10;65(21):14740-14763. |