| Bioactivity | Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively[1]. |
| Invitro | Multi-kinase-IN-5 (compound 15c) 对国家癌症研究所 (NCI) 60 种细胞系中的大多数细胞表现出积极的抗增殖活性，平均生长抑制率为 61.83%，针对 MCT-7、DU 145 和 HCT-116 细胞系 的 IC50 值分别为 4.39、1.06 和 0.34 nM[1]。 0 --> Multi-kinase-IN-5 相关抗体: |
| Name | Multi-kinase-IN-5 |
| Formula | C19H15N5O2S |
| Molar Mass | 377.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ismail RSM, et al. Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents. BMC Chem. 2023 Jul 18;17(1):81. |