| Bioactivity | HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC50 value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury[1]. |
| Invitro | HMGB1-IN-1 (compound 6) （0-30 μM，0-48 h）不仅降低 RAW264.7 细胞和 HK-2 细胞中 IL-1β 和 TNF-α 的水平，而且下调 NLRP3、P-NF-κB p65 和 HMGB1 在活化的 HK-2 细胞中呈剂量依赖性[1]。 0 --> HMGB1-IN-1 相关抗体: |
| In Vivo | HMGB1-IN-1 (compound 6) （15-30 mg/kg，腹腔注射）显示出良好的抗炎活性[1]。 Animal Model: |
| Name | HMGB1-IN-1 |
| Formula | C57H75N3O15 |
| Molar Mass | 1042.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qiang X, et al. Synthesis of glycyrrhizin analogues as HMGB1 inhibitors and their activity against sepsis in acute kidney injury. Eur J Med Chem. 2023 Nov 5;259:115696. |