Monophosphoryl lipid A_product_DataBase

Bioactivity	Monophosphoryl lipid A (Glucopyranosyl lipid A) is a toll-like receptor 4 agonist. Monophosphoryl lipid A is derived from the cell wall of nonpathogenic Salmonella. Monophosphoryl lipid A can be used for the research of immunization and vaccine[1].
Invitro	Monophosphoryl lipid A (100 μg/ml, 2 hours; dendritic cells) induces NF-κB activation and modulates TLR2[2].Monophosphoryl lipid A (5~100 μg/ml, 24 hours; dendritic cells) induces IL-12 production by human[2].Increasing the amount of Monophosphoryl lipid A (from 0.1 to 1 μg), the percentage of matured BMDCs also increased[1]. Monophosphoryl lipid A up-regulates dendritic cells surface markers. Monophosphoryl lipid A enhances T cell responses. Monophosphoryl lipid A (CD4 T cells) increases calcium mobilization of activated T cells[2]. Western Blot Analysis[2] Cell Line:
In Vivo	The generated Monophosphoryl lipid A has been shown to activate APC and to enhance the generation of both Th1- and Th2-specific immune response in mice[2].
Name	Monophosphoryl lipid A
CAS	1246298-63-4
Formula	C96H184N3O22P
Molar Mass	1763.47
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Cheng R, et al. Recombination Monophosphoryl Lipid A-Derived Vacosome for the Development of Preventive Cancer Vaccines. ACS Appl Mater Interfaces. 2020;12(40):44554-44562. [2]. Ismaili J, et al. Monophosphoryl lipid A activates both human dendritic cells and T cells. J Immunol. 2002;168(2):926-932.

PeptideDB

Monophosphoryl lipid A

CAS: 1246298-63-4 F: C96H184N3O22P W: 1763.47