PeptideDB

IRAK4-IN-4

CAS: 1850276-58-2 F: C22H16N2O2 W: 340.37

IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compou
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Bioactivity IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor extracted from patent CN107163044A, Compound15, has an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM[1].
Target IC50: 2.8 nM (IRAK4), 2.1 nM (cGAS)
Name IRAK4-IN-4
CAS 1850276-58-2
Formula C22H16N2O2
Molar Mass 340.37
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. One class has the naphthalene second dione compounds and its derivative of protease modification activities. CN107163044A.