| Bioactivity | Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OCTN2. Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Mildronate (Meldonium) treatment-induced redirection of long-chain FA metabolism from mitochondria to peroxisomes[1]. | ||||||||||||
| Target | IC50: 34-62 μM (human recombinant BBOX).EC50: 21 μM (human OCTN2). | ||||||||||||
| Name | Mildronate dihydrate | ||||||||||||
| CAS | 86426-17-7 | ||||||||||||
| Formula | C6H18N2O4 | ||||||||||||
| Molar Mass | 182.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Dambrova M, et al. Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity. Pharmacol Res. 2016 Nov;113(Pt B):771-780. [2]. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25. |
Mildronate dihydrate
CAS: 86426-17-7 F: C6H18N2O4 W: 182.22
Mildronate dihydrate (Meldonium dihydrate) functions as a cardioprotective drug by cpmpetetively inhibiting BBOX1 and OC
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