| Bioactivity | Neoline, the active ingredient of processed aconite root (PA), alleviated oxaliplatin-induced peripheral neuropathy in mice. Neoline can be used as a marker compound to determine the quality of the PA products for the treatment of neuropathic pain[1]. |
| Name | Neoline |
| CAS | 466-26-2 |
| Formula | C24H39NO6 |
| Molar Mass | 437.57 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Tanimura Y, et al. Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats.J Ethnopharmacol. 2019 Sep 15;241:111859. [2]. Nakatani Y, Negoro K, Yamauchi M, et al. Neoline, an active ingredient of the processed aconite root in Goshajinkigan formulation, targets Nav1.7 to ameliorate mechanical hyperalgesia in diabetic mice. J Ethnopharmacol. 2020;259:112963. |