Methylprednisolone aceponate_product_DataBase

Bioactivity	Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders[1][2][3].
Invitro	Methylprednisolone aceponate 抑制胶原酶启动子活性 (在 HeLa 细胞中)、LPS 诱导的 IL-12p40 分泌 (在人 PBMC 中) 和植物凝集素诱导的 IFN-γ 分泌 (在人 PBMC 中)，IC50s 分别为 9.3 , 16.8, 15.2 nM[3].Methylprednisolone aceponate 激活 MMTV 启动子和 TAT 活性，EC50 分别为 21.8 和 20.5 nM[3]。
In Vivo	Methylprednisolone aceponate (局部应用, 50 μL, 巴豆油引起的伊文蓝水肿模型) 具有抗炎作用，IC50 为 0.0015%，全身副作用低[1].Methylprednisolone aceponate (0.0001%-0.1%，局部应用) 在小鼠和大鼠的刺激性接触性皮炎中抑制水肿形成，ED50 为 0.002%[3]。 Animal Model:
Name	Methylprednisolone aceponate
CAS	86401-95-8
Formula	C27H36O7
Molar Mass	472.57
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders -- a clinical update. Int J Clin Pract. 2006 Jan;60(1):85-92. [2]. H.J. Zentel, et al. Preclinical evaluation of a new topical corticosteroid methylprednisolone aceponate. 1994. 3 (s1), S32-S38. [3]. Schäcke H, et al. Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol. 2009 Oct;158(4):1088-103.

PeptideDB

Methylprednisolone aceponate

CAS: 86401-95-8 F: C27H36O7 W: 472.57