| Bioactivity | COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-27 shows anti-inflammatory activity[1]. |
| Invitro | COX-2-IN-27 (compound 15b) shows significant COX-2 selectivity with an SI value of 293.78[1]. |
| In Vivo | COX-2-IN-27 (28 µM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 93.20% and 109.08% in 4h and 3h, respectively[1]. |
| Name | COX-2-IN-27 |
| CAS | 2413565-17-8 |
| Formula | C29H24ClN7S3 |
| Molar Mass | 602.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. |
COX-2-IN-27
CAS: 2413565-17-8 F: C29H24ClN7S3 W: 602.20
COX-2-IN-27 is a potent and selective COX-2 inhibitor with IC50 values of 13.22, 0.045, 1.67 µM for COX-1, COX-2, 15-LO
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