| Bioactivity | Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS)[1]. |
| Target | IC50: 70 μM (hDDAH, Dimethylarginine dimethylaminohydrolase) |
| CAS | 150403-96-6 |
| Formula | C8H18ClN3O2 |
| Molar Mass | 223.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kotthaus J, et al. Structure–activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads[J]. Bioorganic & medicinal chemistry, 2008, 16(24): 10205-10209. |
Methyl-L-NIO hydrochloride
CAS: 150403-96-6 F: C8H18ClN3O2 W: 223.70
Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethyla
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