| Bioactivity | Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstriction and increased peripheral vascular resistance[1][2]. Methoxamine hydrochloride significantly increased the overflow of ATP, ADP and AMP, but not adenosine, by a prazosin-sensitive mechanism in the rabbit pulmonary artery[3]. | ||||||||||||
| Target | Noradrenergic α1. | ||||||||||||
| In Vivo | Methoxamine (0.025 mg/kg; femoral vein) hydrochloride has a greater effect on peripheral resistance vessels than on Winkessel vessels in the rat systemic circulation[2]. Animal Model: | ||||||||||||
| Name | Methoxamine hydrochloride | ||||||||||||
| CAS | 61-16-5 | ||||||||||||
| Formula | C11H18ClNO3 | ||||||||||||
| Molar Mass | 247.72 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sanders AB. The roles of methoxamine and norepinephrine in electromechanical dissociation. Ann Emerg Med. 1984;13(9 Pt 2):835-839. [2]. Chang KC. Hypertensive effects of methoxamine on arterial mechanics in rats: analysis based on exponentially tapered T-tube model. Eur J Pharmacol. 1998;350(2-3):195-202. [3]. Takeuchi K, et al. Methoxamine-induced release of endogenous ATP from rabbit pulmonary artery. Eur J Pharmacol. 1994;254(3):287-290. |
Methoxamine hydrochloride
CAS: 61-16-5 F: C11H18ClNO3 W: 247.72
Methoxamine hydrochloride is a selective alpha1-adrenergic receptor agonist. Methoxamine hydrochloride causes vasoconstr
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