| Bioactivity | MenA IN-1 is an effective inhibitor of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis (MTB) with an IC50 value of 13 µM and an GIC50 value of 8 µM. MenA IN-1 can be used to curb the continuous spread of tuberculosis[1]. |
| Target | IC50: 13 µM (1,4-dihydroxy-2-naphthoate isoprenyltransferase, MenA) |
| Invitro | MenA IN-1 (compound 2) (50 µM ) 对结核分枝杆菌 (MTB) 有杀菌作用，当与 Q203 (HY-101040) 或 IMP (HY-108213) 联用时，显著增强杀菌效果[1]。 |
| Name | MenA-IN-1 |
| Formula | C29H36N2O2 |
| Molar Mass | 444.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023 Jan 18;249:115125. |