| Bioactivity | Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3]. |
| Invitro | Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1].Melflufen hydrochloride induces apoptosis in MM.1S cells[1].Melflufen hydrochloride also is a potent activator of exosome secretion[3]. Cell Viability Assay[1] Cell Line: |
| Name | Melflufen hydrochloride |
| CAS | 380449-54-7 |
| Formula | C24H31Cl3FN3O3 |
| Molar Mass | 534.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
Melflufen hydrochloride
CAS: 380449-54-7 F: C24H31Cl3FN3O3 W: 534.88
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen hyd
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