| Bioactivity | (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1]. | ||||||||||||
| Name | (5Z,2E)-CU-3 | ||||||||||||
| CAS | 1815598-71-0 | ||||||||||||
| Formula | C16H12N2O4S3 | ||||||||||||
| Molar Mass | 392.47 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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(5Z,2E)-CU-3
CAS: 1815598-71-0 F: C16H12N2O4S3 W: 392.47
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitiv
Data collection：peptidedb@qq.com
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