| Bioactivity | MeS-IMPY showed a high binding affinity to β-amyloid plaques extracted from Alzheimer's disease (AD) human brains or AD brain homogenates compared to IMPY (Ki=7.93 and 8.95 nM, respectively). [11C]MeS-IMPY is a potential radioligand for imaging β-amyloid plaques with positron emission tomography (PET)[1][2]. |
| CAS | 955376-42-8 |
| Formula | C16H17N3S |
| Molar Mass | 283.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Seneca N, et al. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34(6):681-9. [2]. Seneca N, et al. Low retention of [S-methyl-11C] MeS-IMPY to β-amyloid plaques in patients with Alzheimer's disease[J]. Current Radiopharmaceuticals, 2009, 2(2): 129-136. |