| Bioactivity | DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells[1][2]. |
| CAS | 904309-12-2 |
| Formula | C18H10BrF3N4 |
| Molar Mass | 419.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang YY, et, al. TRPV1 Antagonist DWP05195 Induces ER Stress-Dependent Apoptosis through the ROS-p38-CHOP Pathway in Human Ovarian Cancer Cells. Cancers (Basel). 2020 Jun 26;12(6):1702. [2]. Lee J, et, al. A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers. Drug Des Devel Ther. 2017 Apr 24:11:1301-1313. |
DWP-05195
CAS: 904309-12-2 F: C18H10BrF3N4 W: 419.20
DWP-05195 is a TRPV1 antagonist that can inhibit the pain signal transduction. DWP-05195 induces ER stress-dependent apo
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