Mavorixafor hydrochloride

CAS: 880549-30-4 F: C21H28ClN5 W: 385.93

Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of

Contact QiTai

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	Mavorixafor (AMD-070) hydrochloride is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding. Mavorixafor hydrochloride also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 nM and 9 nM, respectively[1].
Invitro	Mavorixafor (AMD-070) hydrochloride 对其他趋化因子受体（CCR1、CCR2b、CCR4、CCR5、CXCR1 和 CXCR2）没有影响[1]。Mavorixafor（6.6 µM；14-21 天）hydrochloride 显着抑制 B88-SDF-1 细胞的贴壁依赖性生长。Mavorixafor hydrochloride 显着损害 B88-SDF-1 细胞增强的运动性。Mavorixafor hydrochloride 还显着抑制 B88-SDF-1 细胞的迁移和 Matrigel 侵袭[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Mavorixafor hydrochloride 相关抗体: Cell Invasion Assay[2] Cell Line:
In Vivo	Mavorixafor (2 mg/kg；口服；每天一次；持续 49 天) hydrochloride 显着抑制裸鼠 B88-SDF-1 细胞的肺转移[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	880549-30-4
Formula	C21H28ClN5
Molar Mass	385.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88. [2]. Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.

Methyl-4-oxoretinoate