| Bioactivity | LRRK2-IN-13 (Compound 13) is an inhibitor of LRRK2 (IC50=0.57 nM). LRRK2-IN-13 has brain penetrating properties[1]. |
| Invitro | LRRK2-IN-13 对 LRRK2 的抑制效果分别为 IC50=0.57 nM (WT), 0.22 nM (LRRK2 G2019S)， 0.33 nM (LRRK2 WT ADPGIo)[1]。LRRK2-IN-13 (0.05 μΜ; 1-120 min) 在肝细胞内在的清除率为 1.88 (L/h/kg)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> LRRK2-IN-13 相关抗体: |
| CAS | 3032733-17-5 |
| Formula | C19H19ClN8O2 |
| Molar Mass | 426.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jensen, T, et al. Preparation of substituted 2,4,12,13-tetrahydro-11H-5,7-(azenometheno)dipyrazolo[3,4-b:5',1'-g][1]oxa[4,6,8]triazacycloundecine derivatives as leucine-rich repeat kinase 2 (LRKK2) inhibitors. World Intellectual Property Organization, WO2024056775 A1 2024-03-21 |