| Bioactivity | Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist[1]. | ||||||||||||
| Invitro | For antagonistic activity, (−)-mavoglurant, the (−)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1]. | ||||||||||||
| Name | Mavoglurant racemate | ||||||||||||
| CAS | 1636881-61-2 | ||||||||||||
| Formula | C19H23NO3 | ||||||||||||
| Molar Mass | 313.39 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-80 |
Mavoglurant racemate
CAS: 1636881-61-2 F: C19H23NO3 W: 313.39
Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 re
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