| Bioactivity | Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2]. | ||||||||||||
| Invitro | Macozinone (PBTZ169) is highly potent against M. tuberculosis in vitro, ex vivo, and in vivo[2]. | ||||||||||||
| Name | Macozinone | ||||||||||||
| CAS | 1377239-83-2 | ||||||||||||
| Formula | C20H23F3N4O3S | ||||||||||||
| Molar Mass | 456.48 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Macozinone
CAS: 1377239-83-2 F: C20H23F3N4O3S W: 456.48
Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase)
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