Fenbendazole_product_DataBase

Bioactivity

Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1].

Invitro

芬苯达唑 (1 uM; 24 小时) 在野生型 p53 的人非小细胞肺癌 (NSCLC) 的肿瘤细胞系 (H460 和 A549) 中显着抑制细胞生长[1]。芬苯达唑 (1 uM; 24 小时) 诱导细胞凋亡并导致线粒体 p53 蛋白水平升高[1]。芬苯达唑 (1 uM; 24 小时) 可以引起人 NSCLC 细胞的有丝分裂期细胞的周期停滞[1]。芬苯达唑 (1 uM; 24 小时) 可以导致 A549 细胞微管网络的部分改变[1]。 Cell Cycle Analysis[1] Cell Line:

Name

Fenbendazole

CAS

43210-67-9

Formula

C15H13N3O2S

Molar Mass

299.35

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

Fenbendazole

CAS: 43210-67-9 F: C15H13N3O2S W: 299.35