| Bioactivity | MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33 μM. |
| Target | Ki: 33 μM (glycineB) |
| Invitro | MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM[1]. |
| In Vivo | MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid[1]. |
| Name | MRZ 2-514 |
| CAS | 202808-11-5 |
| Formula | C11H6BrN3O3 |
| Molar Mass | 308.09 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Parsons CG, et al. Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Journal of Pharmacology and Experimental Therapeutics (1997), 283(3), 126 |
MRZ 2-514
CAS: 202808-11-5 F: C11H6BrN3O3 W: 308.09
MRZ 2-514 is an antagonist of the strychnine-insensitive modulatory site of the NMDA receptor (glycineB), with Ki of 33
Data collection：peptidedb@qq.com
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